ABSTRACT
In this study, we formulated and analyzed a deterministic mathematical model for the co-infection of COVID-19 and tuberculosis, to study the co-dynamics and impact of each disease in a given population. Using each disease's corresponding reproduction number, the existence and stability of the disease-free equilibrium were established. When the respective threshold quantities R C , and R T are below unity, the COVID-19 and TB-free equilibrium are said to be locally asymptotically stable. The impact of vaccine (i.e., efficacy and vaccinated proportion) and the condition required for COVID-19 eradication was examined. Furthermore, the presence of the endemic equilibria of the sub-models is analyzed and the criteria for the phenomenon of backward bifurcation of the COVID-19 sub-model are presented. To better understand how each disease condition impacts the dynamics behavior of the other, we investigate the invasion criterion of each disease by computing the threshold quantity known as the invasion reproduction number. We perform a numerical simulation to investigate the impact of threshold quantities ( R C , R T ) with respect to their invasion reproduction number, co-infection transmission rate ( ß c t ) , and each disease transmission rate ( ß c , ß t ) on disease dynamics. The outcomes established the necessity for the coexistence or elimination of both diseases from the communities. Overall, our findings imply that while COVID-19 incidence decreases with co-infection prevalence, the burden of tuberculosis on the human population increases.
ABSTRACT
Infectious diseases have remained one of humanity's biggest problems for decades. Multiple disease infections, in particular, have been shown to increase the difficulty of diagnosing and treating infected people, resulting in worsening human health. For example, the presence of influenza in the population is exacerbating the ongoing COVID-19 pandemic. We formulate and analyze a deterministic mathematical model that incorporates the biological dynamics of COVID-19 and influenza to effectively investigate the co-dynamics of the two diseases in the public. The existence and stability of the disease-free equilibrium of COVID-19-only and influenza-only sub-models are established by using their respective threshold quantities. The result shows that the COVID-19 free equilibrium is locally asymptotically stable when R C < 1 , whereas the influenza-only model, is locally asymptotically stable when R F < 1 . Furthermore, the existence of the endemic equilibria of the sub-models is examined while the conditions for the phenomenon of backward bifurcation are presented. A generalized analytical result of the COVID-19-influenza co-infection model is presented. We run a numerical simulation on the model without optimal control to see how competitive outcomes between-hosts and within-hosts affect disease co-dynamics. The findings established that disease competitive dynamics in the population are determined by transmission probabilities and threshold quantities. To obtain the optimal control problem, we extend the formulated model by including three time-dependent control functions. The maximum principle of Pontryagin was used to prove the existence of the optimal control problem and to derive the necessary conditions for optimum disease control. A numerical simulation was performed to demonstrate the impact of different combinations of control strategies on the infected population. The findings show that, while single and twofold control interventions can be used to reduce disease, the threefold control intervention, which incorporates all three controls, will be the most effective in reducing COVID-19 and influenza in the population.